She began her career in 1979 as an in-house consultant at CIWLT (Compagnie des Wagons Lits & du Tourisme).
In March 1984 she joined Renault and held various management posts in the Organization, Marketing and Sales and Human Resources departments before joining Nissan Europe in 2001 as Vice President, Human Resources and General Affairs for Europe Region. She was a member of Nissan Europe's Management Committee.

In November 2005, Marie-Françoise Damesin comes back in Renault as Senior Vice President Communications for Renault. From November 2nd 2010, she is appointed Group Human Resources Senior Vice President. She is member of the Renault management committee since 2005.

As of April 11th 2011, Marie-Françoise Damesin, has joigned the Renault Group Executive Committee as Human Resources Executive Vice President.